DESCRIPTIONS OF CHEMISTRY GRADUATE COURSES

EASTERN KENTUCKY UNIVERSITY

Explanation of Course Descriptions

The semester hours which may be earned by successful completion of a course are indicated in parentheses immediately following the course title, e.g., (3). I, II and A used in the description of a course indicate the course will be offered in the fall semester, spring semester and by announcement, respectively. A course is offered during the indicated semester or by announcement on the assumption there will be adequate enrollment. If a course does not obtain adequate enrollment, it is subject to cancellation.

The description of the course format for courses which include a laboratory experience is found at the end of the course description. A course which consists of three hours of classroom lecture and two hours of laboratory is described as "3 Lec/2 Lab."

CHE 701 Chemtopics: ________. (1-3) A. Prerequisite: instructor approval. Topics to be chosen from a current and/or specialized area of chemistry such as environmental chemistry or industrial chemistry, and will vary according to students' needs. May be retaken to a maximum of six hours. Some of the topics covered in the last few years under this course number are shown below.

· Mass Spectrometry (3) A. Prerequisites: CHE 362, CHE 325, or instructor approval. Types of mass spectrometers and mass analyzers, sample inlet systems, ionization techniques, detectors, vacuum systems,interpretation of mass spectra, GC-MS, LC-MS, and applications of MS.

· Chemistry of Interfaces. (3) A. Prerequisite: CHE 470 or 471, or instructor approval. Chemical principles and phenomena as they apply to interfaces (gas/liquid, gas/solid, liquid/liquid, and liquid/solid). Both theoretical and experimental aspects will be emphasized, as well as practical consequences and applications.

CHE 715 Analysis and Characterization. (4) II. Prerequisites: CHE 362, 367, 471, 550 or department approval. Synthesis, separation, and characterization of inorganic and organic compounds and mixtures. Included will be spectroscopic techniques, preparation of derivatives and methods appropriate for handling of air sensitive compounds and those of low thermal stability. 2 Lec/6 Lab.

CHE 725 Instrumental Methods. (4) A. Prerequisites: CHE 325, 362, 367. Corequisite: 471, or instructor approval. Methods of spectroscopic analysis; electrochemical methods; chromatographic methods. Emphasis placed on broad, functional approach to instrumental techniques. 2 Lec/6 Lab.

CHE 730 Biochemistry I, (4) A. Prerequisites: CHE 362, 367, 471 instructor approval. Chemistry, metabolism, and biosynthesis of carbohydrates, proteins, and lipids; the action of vitamins, hormones, and enzymes related to cellular metabolism and body processes. 3 Lec/3 Lab.

CHE 731 Biochemistry II, (3) A. Prerequisite: CHE 730. Continuation of CHE 730. Topics included are nucleoproteins, energetics, biological catalysis, and functions of biologically important materials.

CHE 734 Introduction to Medicinal Chemistry. (3) A. Prerequisites: one semester each in organic and biochemistry. Introductory study of medicinal agents at the molecular level. Pharmacokinetics, drug metabolism, chemical structure-medicinal activity relationships, selective toxicity.

CHE 750 Inorganic Chemistry. (3) I. Prerequisite: CHE 472 or instructor approval. Modern concepts of atomic nuclei, atomic structure, and classification of elements. Complex ions and coordination compounds. Theories of bonding.

CHE 760 Mechanistic Chemistry. (3) A. Prerequisites: CHE 362, 367, 472 or instructor approval. Survey of new reactions and comprehensive study of reaction mechanisms.

CHE 772 Advanced Physical Chemistry. (3) A. Prerequisite: CHE 472 (MAT 353 recommended) or instructor approval. Intermediate and advanced topics in thermodynamics, kinetics, structure and bonding.

CHE 785 Principles of High Polymers. (3) A. Prerequisites: CHE 362, 367. Preparation and characterization of high polymers; monomers, condensation and addition polymerization; radical, anionic, and cationic initiation. Emphasis on microstructure of the polymer chain and its effect on macromolecular physical properties. 2 Lec/3 Lab.

Selected Topics in Chemistry (1-3) A. Prerequisite: instructor approval. Topics chosen from advanced areas of interest and vary according to needs. May be retaken for credit when new topics offered. Topics covered in the last few years for the various selected topic courses are shown below.

CHE 802 Selected topics in Analytical Chemistry.

· Gas Chromatography-Mass Spectrometry. (3) A. Emphasis on high resolution capillary chromatography for sample separation and introduction into typical bench-top mass spectrometers. MS data systems, hardware maintenance and trouble shooting.

CHE 803 Selected topics in Biochemistry.

· Physical Biochemistry. (3) A. Prerequisite: CHE 471 or 470 and CHE 530/730 or instructor approval. Application of principles of physical chemistry to macromolecules, especially proteins and nucleic acids. This course covers molecular spectroscopy, multiple equilibria, protein-ligand complexes, theories of protein purification, the kinetics of macromolecule formation and action, and the use of computers in modeling proteins.

· Immunochemistry. (3) A. Prerequisite: CHE 471 or 470 and CHE 530/730 or instructor approval. The chemistry of the immune system. Topics of antibody and T-cell receptor structure and function and the origin of antibody diversity are discussed. Molecular events initiating the immune response, mechanisms by which antibodies are used in both diagnostic and therapeutic procedures, theories of immune system differentiation, nature of self vs. non-self recognition, signal generation in the immune response, and the complement cascade are covered. Future trends such as the use of antibodies in drug delivery systems are also examined.

CHE 805 Selected topics in Inorganic Chemistry.

· Bioinorganic Chemistry. (3) A. Prerequisite: CHE 750 or instructor approval. Inorganic elements in biology: occurrence, function, structural and mechanistic studies. The chemistry of inorganic radiopharmaceuticals and chemotherapeutically active inorganic compounds.

CHE 806 Selected topics in Organic Chemistry.

CHE 807 Selected topic in Physical Chemistry.

· Physical Surface Chemistry. (3) A. Prerequisite: CHE 470 or 471, or instructor approval. Chemical principles and phenomena as they apply to interfaces (gas/liquid, gas/solid, liquid/liquid, and liquid/solid). Both theoretical and experimental aspects will be emphasized, as well as practical consequences and applications.

CHE 822. Advanced Analytical Chemistry. (3) A. Prerequisite: CHE 525/725 or instructor approval. Modern practices in chemical analysis. Sampling, sample preparation, spectroscopic and chromatographic methods.

CHE 839 Cooperative Study: Chemistry. (3-6) A. Prerequisite: department approval. Work under faculty and field supervisors in cooperative placement. Three to six hours per semester or summer. May be retaken at discretion of Department or College. Eighty hours work for each credit. Maximum of two credit hours may apply to M.S. degree in Chemistry.

CHE 845 Chemical Laboratory and Demonstration Techniques. (1-4) A. Prerequisites: six semesters of undergraduate work in chemistry or instructor approval. Techniques of constructing and demonstrating apparatus to illustrate principles of chemistry. Primarily for high school and junior college science teachers. 3-13 Lab.

CHE 850 Advanced Inorganic Chemistry. (3) A. Prerequisite: CHE 550/750. Molecular symmetry in inorganic chemistry, mechanisms of inorganic reactions, and catalysis by coordination and organometallic complexes.

CHE 880 Graduate Seminar. (1) II. Presentation of significant developments in chemistry to members of the chemistry faculty and department majors. May be retaken to a maximum of two hours.

CHE 890 Graduate Literature and Project Planning. (1) A. Extensive survey of the literature related to a specific research program and planning of that program through consultation with a selected research advisor.

CHE 892 Graduate Project. (3) A. Research of chemical literature and preparation of a detailed report on a current topic in chemistry. The topic of the paper shall be pre-approved by the student's committee.

CHE 895 Graduate Research. (1-6) A. Laboratory research in one of the major areas of chemistry for application to a thesis. May be retaken to a maximum of six hours.

CHE 895C Continuation of Graduate Research. (1-9) A. Prerequisite: departmental approval. The continuation of laboratory research in one of the major areas of chemistry for application to a thesis. May be retaken as necessary to complete research thesis. A student must have registered for six hours of CHE 895 before registering for CHE 895C. May not be used to satisfy degree program requirements.